Sequence variation at the human FOXO3 locus: a study of premature ovarian failure and primary amenorrhea
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چکیده
منابع مشابه
Sequence variation at the human FOXO3 locus: a study of premature ovarian failure and primary amenorrhea.
BACKGROUND The forkhead transcription factor Foxo3 is a master regulator and potent suppressor of primordial follicle activation. Loss of Foxo3 function in the mouse leads to premature ovarian failure (POF) due to global follicle activation. METHODS AND RESULTS Here, we show that the mouse Foxo3 locus is haploinsufficient, and that Foxo3-/+ females undergo early reproductive senescence consis...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2007
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/dem255